7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity
نویسندگان
چکیده
منابع مشابه
Crystal structure of 2-[(5',6',7',8'-tetrahydro-5',5',8',8'-tetramethyl)-2'-naphthyl]-1-ethyl-1H-benzimidazole-5-carboxylic acid ethyl ester.
retinoids with a tetrahydronaphthalene structure (Fig. 1), was synthesized using an NaHSO3 addition product of 5,6,7,8tetrahydro-5,5,8,8-tetramethyl-2-naphthalene-carboxaldehyde (compound I) as a starting material, which was prepared as described.1 The condensation of compound I and 4-ethylamino3-amino-ethylbenzoate (mp: 73 ̊C) in DMF for 70 h gave the title compound (recrystallized from hexane/...
متن کامل7-Benzenesulfonamido-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid methanol solvate
In the title compound, C(15)H(14)N(2)O(5)S(2)·CH(4)O, the six-membered ring fused to the β-lactam unit adopts a twisted conformation. In the crystal structure, the component mol-ecules are linked into a three-dimensional framework through inter-molecular N-H⋯S, N-H⋯O and O-H⋯O hydrogen bonds and C-H⋯O contacts.
متن کامل7-Benzenesulfonamido-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]octa-2-ene-2-carboxylic acid monohydrate
In the title compound, C(14)H(14)N(2)O(5)S(2)·H(2)O, the six-membered ring fused to the β-lactam unit has a twisted conformation. Weak intra-molecular N-H⋯S and C-H⋯O inter-actions occur. Inter-molecular C-H⋯S, N-H⋯O, C-H⋯O and O-H⋯O hydrogen-bonding inter-actions stabilize the crystal structure, forming a three-dimensional network. Weak C-H⋯π inter-actions are also present.
متن کاملSynthesis and transformations of di-endo-3-aminobicyclo-[2.2.2]oct-5-ene-2-carboxylic acid derivatives.
all-endo-3-amino-5-hydroxybicyclo[2.2.2]octane-2-carboxylic acid (13) and all-endo-5-amino-6-(hydroxymethyl)bicyclo[2.2.2]octan-2-ol (10) were prepared via dihydro-1,3-oxazine or g-lactone intermediates by the stereoselective functionalization of an N-protected derivative of endo-3-aminobicyclo[2.2.2]oct-5-ene-2-carboxylic acid (2). Ring closure of b-amino ester 4 resulted in tricyclic pyrimidi...
متن کامل2-(2-Chlorophenyl)-5-methyl-1,3-dioxane-5-carboxylic acid
In the title compound, C(12)H(13)ClO(4), the 1,3-dioxane ring adopts a chair conformation and the 2-chloro-benzene and methyl substituents occupy equatorial sites. The carboxyl group is in an axial inclination. In the crystal, carb-oxy-lic acid inversion dimers linked by pairs of O-H⋯O hydrogen bonds generate R(2) (2)(8) loops.
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ژورنال
عنوان ژورنال: Journal of the Serbian Chemical Society
سال: 2004
ISSN: 0352-5139,1820-7421
DOI: 10.2298/jsc0411919o